• Virtual screening and in vitro evaluation of putative positive allosteric modulators of the GABAB receptor 

      Issifou, Ibrahim Toure (Mastergradsoppgave; Master thesis, 2020-05-14)
      -aminobutyric acid (GABA) is the chief inhibitory neurotransmitter of the central nervous system (CNS). GABA exhibits its function by binding to either the ionotropic GABAA receptor or the metabotropic GABAB receptor, causing a decrease in activity in the nervous system. Disruption in the GABAergic system has been associated with various neurological conditions, including Alzheimer’s disease, anxiety, ...